微图:人类微生物组代谢的网络可视化资源
Cyrille C Thinnes1,2,3,4, Renee Waschkowitz1,2,3,4, Eoghan Courtney5
1Digital Metabolic Twin Centre, University of Galway, Galway, Ireland.
NPJ biofilms and microbiomes
|November 28, 2025
概括
我们开发了MicroMap,这是一种新的网络可视化工具,用于探索超过25万个微生物基因组规模代谢重建的代谢. 这个资源有助于理解微生物群.
科学领域:
- 微生物组研究的研究.
- 代谢网络分析代谢网络分析
- 计算生物学是一种计算生物学.
背景情况:
- 人类微生物组显著影响宿主的新陈代谢和健康.
- 基于约束的重建和分析 (COBRA) 对微生物组研究至关重要.
- 缺乏大规模可视化工具阻碍了微生物组代谢的探索.
研究的目的:
- 为微生物组代谢创建一个全面的网络可视化.
- 为了使微生物代谢能力的直观探索和比较.
- 支持计算建模社区和教育.
主要方法:
- 开发了MicroMap,一个手动策划的网络可视化.
- 整合了超过四分之一百万微生物基因组规模的代谢重建.
- 包括5064种反应,3499种代谢物和98种药物.
主要成果:
- MicroMap可视化了257,429个微生物重建的新陈代谢.
- 便于直观地探索微生物组的代谢能力.
- 提供了微生物之间代谢功能的比较分析.
结论:
- MicroMap为微生物组代谢可视化提供了一个可扩展的解决方案.
- 提高对营养-宿主-微生物组-疾病轴的理解.
- 作为一个教育资源,并与VMH和COBRA工具箱等现有工具集成.
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