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在DoRIS随机对照试验中,不同的HPV疫苗方案引起的B细胞记忆

Rebecca Wiggins¹, Kathy J Baisley², Jackton Indangasi^2,3

¹York Biomedical Research Institute, Hull York Medical School, University of York, York, UK. rebecca.wiggins@york.ac.uk.

|November 28, 2025

概括

人类乳头瘤病毒 (HPV) 疫苗产生持久的免疫记忆细胞 (MBC). 在坦桑尼亚的女孩中,即使是一剂HPV疫苗也会诱导可检测的MBC三年,这表明潜在的长期保护.

科学领域:

免疫学免疫学免疫学
疫苗学疫苗学疫苗学
公共卫生公共卫生

背景情况:

预防性人类乳头瘤病毒 (HPV) 疫苗对于预防HPV相关疾病至关重要.
记忆B细胞 (MBCs) 是接种疫苗后持续免疫反应的关键指标.
了解疫苗剂量对MBC的影响对于优化疫苗接种策略至关重要.

研究的目的:

评估HPV特异性MBC的频率和持续性,以应对不同剂量的Cervarix®和Gardasil®9.
评估单剂量与多剂量HPV疫苗接种方案的长期免疫性.
研究MBCs在HPV疫苗接种后的长期保护中的作用.

主要方法:

剂量减少免疫桥梁和安全研究 (DoRIS) 涉及930名坦桑尼亚女孩.
参与者接受了Cervarix®或Gardasil®9.9的1,2或3剂量.
在基线和在5次接种疫苗后访问中使用酶相关的免疫吸收点检量化HPV特异性MBC,长达36个月.

主要成果:

超过90%的参与者在所有时间点都表现出可检测的MBC,在7个月左右达到顶峰.
在7个月后,在2剂和3剂组中,MBC频率和响应者比例下降.
单剂量接受者的MBC频率低于多剂量接受者的MBC频率,但在36个月,对HPV16和18的HPV16和18的反应在所有手臂中都是相似的.

结论:

接种HPV疫苗,即使是一次剂量,也会引起至少三年持续的MBC反应.
这些发现表明,单剂量HPV疫苗接种策略可能会提供长期的保护.
需要进一步评估,以确定剂量反应对长期免疫的影响的临床意义.

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