肠道微生物群和骨质之间的遗传依据的因果关系:质和代谢中介
Peng-Lin Guan1,2,3,4, Cheng-Da Yuan5, Ming-Yu Han6
1College of Life Sciences, Zhejiang University, Hangzhou, China.
Nature communications
|November 28, 2025
概括
某些肠道细菌,如Bifidobacterium adolescentis,可能会导致骨矿物质密度 (BMD) 的降低. 这种效应与n-3脂肪酸代谢有关,可以通过益生菌和omega-3补充剂来抵消.
科学领域:
- 遗传学 是一个遗传学.
- 微生物学 微生物学
- 代谢过程中的代谢.
- 骨生物学 骨生物学 骨生物学
背景情况:
- 主体遗传,肠道微生物群,代谢物和骨代谢之间的复杂相互作用尚未完全理解.
- 研究这些关系对于理解骨健康和制定有针对性的干预措施至关重要.
研究的目的:
- 为了全面调查共享的遗传因素,因果关系,以及肠道微生物群和骨质之间的血液代谢物的作用.
- 探索肠道微生物群的遗传结构及其对估计的脚骨矿物质密度 (eBMD) 的性作用.
主要方法:
- 利用大规模的欧洲人口数据集,估计了1104种肠道微生物群的多基因SNP遗传性.
- 采用孟德尔的随机化和调解分析来确定因果关系和代谢物参与.
- 进行敏感性和验证分析以确认发现.
主要成果:
- 只有8.7%的肠道微生物群表现出显著的多基因遗传性.
- 确定了14种肠道微生物群对eBMD具有性作用的种群,其中11种表明因果关系.
- 发现Bifidobacteriaceae,Bifidobacterium和B. adolescentis因果性地降低了eBMD,可能是通过n-3通路 (77.53%-87.24%) 介导的氨酸水平.
结论:
- 双细菌种群和骨质之间存在一种基因相关的负相关性,可能与宿主微生物相互作用和乳糖不耐受有关.
- 补充双倍细菌益生菌和n-3多不和脂肪酸可能会减轻这种对骨健康的影响.
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