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IL-27Ra促进新生儿死性肠球炎的进展

Yuling Yang¹, Yingyan Liu¹, Limei Zhong²

¹Center for Medical Research On Innovation and Translation, Guangzhou First People's Hospital, the Second Affiliated Hospital of South China University of Technology, Guangzhou, 510000, Guangdong, China.

Scientific reports

|November 29, 2025

概括

介素-27受体α (IL-27Ra) 通过增加炎症和损害肠道屏障,在早产婴儿中加剧死性肠球炎 (NEC). 阻断IL-27Ra可能为NEC提供双重治疗效益.

科学领域:

胃肠病学胃肠病学
免疫学免疫学免疫学
新生儿医学新生儿医学

背景情况:

新生儿死性肠球炎 (NEC) 是早产婴儿的一种严重疾病,其特征是免疫失衡和肠壁缺陷.
介素-27受体α (IL-27Ra) 在NEC病变发生中的作用尚不清楚,尽管它已知在炎症中的双重作用.

研究的目的:

研究IL-27Ra在NEC的发展中的作用.
评估IL-27Ra作为NEC的潜在治疗点.

主要方法:

使用单细胞和大量RNA测序对人类NEC组织进行综合分析.
在一个新生儿小鼠模型中诱导NEC,该模型具有超大胞养,LPS,缺氧和寒冷压力.
评估使用免疫光学,细胞因子分析 (ELISA,qPCR),IL-27Ra淘汰小鼠和组织病理学.

主要成果:

在NEC患者组织的免疫细胞中,IL-27Ra被上调,与促炎细胞因子 (IL-6) 和减少屏障蛋白 (TJP1) 相相关.
在IL-27Ra淘汰的小鼠中,NEC严重程度降低,IL-6水平降低,紧结蛋白表达得到改善.
发现IL-27Ra通过增强肠道炎症和破坏粘膜屏障来促进NEC.

结论:

IL-27Ra在促进NEC病原发生方面发挥着重要作用.
IL-27Ra代表了NEC的一个有前途的治疗点.
针对IL-27Ra信号传递可以同时减少炎症并恢复NEC的肠道屏障功能.

关键词:

在 IL-27Ra 中.肠道屏障肠道屏障肠道屏障肠道炎症是一种肠道炎症.新生儿免疫力新生儿免疫力新生儿死性肠球炎新生儿

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