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苏拉明可以通过抑制cGAS-STING/NF-κB来预防慢性压力诱导的神经行为缺陷

Ojashvi Sharma¹, Amarjot Kaur Grewal², Amit Kumar¹

¹Chitkara College of Pharmacy, Chitkara University, Rajpura, Punjab, 140401, India.

Scientific reports

|November 29, 2025

概括

苏拉明通过抑制cGAS-STING通路和调节NF-κB信号传递,有效地减轻慢性压力诱导的神经行为变化. 这种药物剂量取决于改善小鼠的焦虑,抑郁和认知功能.

科学领域:

神经科学是一个神经科学.
药理学药理学是指药理学的学科.
压力研究压力研究

背景情况:

长时间的压力会导致神经炎症和功能障碍,导致焦虑,抑郁和认知障碍.
cGAS-STING和NF-κB信号通路是中枢神经系统对压力的炎症反应的关键媒介.

研究的目的:

研究cGAS调节器苏拉对由慢性不可预测压力 (CUS) 引起的神经行为变化的影响.
为了检查suramin对神经炎症,氧化压力和神经递质水平的影响,在慢性压力的小鼠模型中.

主要方法:

瑞士白色老鼠被暴露在CUS中8周.
苏拉明在5,10和20毫克/公斤的剂量内内注射.
评估了神经行为测试 (EPM,FST,SPT,TST,MWM,PAT),皮质水平,神经递质测定,氧化应激标志物,神经炎症标志物,ACHE活性和海马/皮质组织学.

主要成果:

苏拉明剂量依赖地改善了神经行为参数,包括焦虑,抑郁和记忆.
苏拉明降低了皮质水平和氧化应激标志物,同时增加了神经递质水平.
苏拉明抑制了cGAS-STING通路并调节了NF-κB信号传递,减少了神经炎症并改善了组织学.

结论:

苏拉明在改善慢性压力诱导的神经行为缺陷方面显示出显著的治疗潜力.
用suramin调节cGAS-STING通路为与压力相关的疾病提供了一种新的治疗策略.
苏拉明有效地恢复了由慢性压力破坏的神经化学和组织学平衡.

关键词:

焦虑焦虑是一种焦虑.慢性不可预测的压力 (CUS)抑郁症抑郁症抑郁症记忆障碍记忆障碍记忆障碍苏拉明·苏拉明 (Suramin Suramin) 是一个著名的通过cGAS-STING/NF-κB通路进行.

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