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Updated: Jan 10, 2026

A Protocol for the Production of KLRG1 Tetramer
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一个LGR二聚体的结构,是糖蛋白激素受体的进化前身

Zhen Gong1, Shuobing Chen1,2, Ziao Fu1,3

  • 1Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA.

Nature communications
|November 29, 2025
PubMed
概括

糖蛋白激素受体 (GpHRs) 作为二聚体而不是单聚体而起作用. 对C. elegans同类菌的结构分析揭示了一种不对称的二元体,能够结合一种激素,与甲状腺刺激激素受体 (TSHR) 复合体中已知的负合作性保持一致.

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