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在宫癌中根据核细胞质一致基因对瘤免疫微环境进行分类

Jiawei Wang^1,2, Anji Chen¹, Qiuling Chen¹

¹Hunan Provincial Key Laboratory of Regional Hereditary Birth Defects Prevention and Control, Hunan Normal University Affiliated Changsha Hospital for Maternal and Child Health Care, Changsha, China.

Scientific reports

|November 29, 2025

概括

核细胞质一致基因 (NCCG) 可以将宫癌患者分为高风险和低风险组. 低风险组显示出更好的生存率,并预测免疫疗法和化疗的反应.

科学领域:

在瘤学瘤学.
基因组学就是基因组学.
分子生物学分子生物学

背景情况:

晚期或复发的宫癌 (CC) 的治疗选择有限.
对于分子生物标志物和新型治疗策略,对CC有着至关重要的需求.

研究的目的:

调查核细胞质一致基因 (NCCG) 在CC和其他上皮癌.
探索NCCG在分子亚型,预后评估和预测治疗反应方面的潜力.

主要方法:

使用单细胞和单核RNA测序识别的NCCG.
使用考克斯回归和ssGSEA,将TCGA-CESC队列分为高风险 (HRG) 和低风险 (LRG) 组.
在对14种表皮衍生的恶性瘤的泛癌分析中验证了NCCG,并评估了预测治疗反应的临床实用性.

主要成果:

NCCG有效地将CC患者分为HRG和LRG,LRG的生存率明显提高 (HR=3.24).
LRG显示免疫细胞透率更高 (CD8+ T和记忆CD4+ T细胞),对免疫疗法 (PD-1/CTLA4抑制剂) 和化疗 (帕诺宾诺斯塔特,多克索鲁比辛) 的敏感性更高.
全癌症分析证实了NCCG的预后相关性和预测治疗疗效的能力.

结论:

在CC和上皮原始癌症中,NCCG对于分子分类和预后评估非常有价值.
NCCG作为预测患者对化疗和免疫疗法的反应的潜在生物标志物.
在宫癌和其他上皮癌中,NCCG为精准医学提供了有希望的新目标.

关键词:

宫癌是发生在宫癌的原因之一.核-细胞质一致的基因预测生物标志物和风险分层.单细胞和单核RNA测序.瘤微环境是一个微环境.

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The Tumor Microenvironment

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