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愤怒有助于持续性败血症诱导的肌肉和线粒体变化

Raphaël Romien¹, Alexandre Pierre^1,2, Sarah Ducastel¹

¹Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167 - RID-AGE - Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, 59000, Lille, France.

Scientific reports

|November 29, 2025

概括

败血症幸存者通常会因为线粒体功能障碍和炎症而经历持续的肌肉衰弱. 向高级甘氨酸最终产品 (RAGE) 的受体可能有助于减轻这些长期肌肉问题.

科学领域:

生物医学科学生物医学科学
分子生物学分子生物学
身体生理学身体生理学

背景情况:

败血症幸存者经常出现持续的肌肉衰弱,但基本机制尚不清楚.
研究败血症对肌肉的长期细胞和分子后果对于患者的康复至关重要.

研究的目的:

在小鼠模型中确定败血症是否导致长期肌肉功能障碍.
确定驱动败血症引起的长期肌肉变化的分子机制.
在这些过程中探索先进糖化最终产品 (RAGE) 受体的作用.

主要方法:

通过使用内注射便泥,建立了复苏性败血症的小鼠模型.
在败血症发生三个月后,分析肌肉的功能,细胞和分子变化.
研究的关键途径包括线粒体呼吸,炎症,氧化应激和RAGE轴.

主要成果:

败血症导致持续的肌肉疲劳,线粒体呼吸减少,三个月后肌肉纤维缩.
氧化应激,线粒体裂变和低级炎症 (NLRP3炎症酶,RAGE) 的标志物被上调.
RAGE淘汰赛小鼠没有长期表现出败血症诱导的肌肉功能障碍,这表明RAGE的关键作用.

结论:

败血症导致长期的肌肉功能障碍,其特征是线粒体变化和慢性炎症.
先进糖化最终产品 (RAGE) 途径的受体与败血症引起的持续肌肉衰弱有关.
向RAGE是一个潜在的治疗策略,用于预防或治疗败血症后的长期肌肉并发症.

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