蛋白尿的改善减轻了静脉血栓栓塞的发生:基于人口的队列研究
Ho Geol Woo1,2, Tae-Jin Song3
1Department of Neurology and Critical Care Medicine, College of Medicine, Kyung Hee University, Seoul, Republic of Korea.
Scientific reports
|November 29, 2025
概括
蛋白尿状态的变化显著影响静脉血栓塞栓症 (VTE) 风险. 持续或进展的蛋白尿增加了静脉瘤发病率,而改善可能会减少它,强调蛋白尿的管理以预防静脉瘤发病.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 心血管医学 心血管医学
- 流行病学 流行病学
背景情况:
- 蛋白尿是已知的静脉血栓塞栓症 (VTE) 的风险因素.
- 蛋白尿水平随着时间的推移而波动,因此需要了解这些变化如何影响VTE风险.
- 种群层面的数据可以阐明动态蛋白尿状态和静脉瘤发生之间的关联.
研究的目的:
- 调查蛋白尿状态的变化与静脉瘤发病率之间的关联.
- 评估蛋白尿严重程度及其时间变化对人口水平VTE风险的影响.
- 为了确定蛋白尿状态的改善是否可以减轻VTE风险.
主要方法:
- 这是一项基于登记册的回顾性研究,使用了来自1,712,507名参与者的健康检查数据.
- 参与者在两个连续时期 (2003-2004年和2005-2006年) 根据蛋白尿状态进行了分类.
- 多变量Cox比例危险模型分析了VTE发生 (深静脉血栓,肺血栓栓塞) 在中位数14.5年的随访期间.
主要成果:
- 在超过14.5年的时间里,45,711名参与者经历了VTE (1.88%的发生率).
- 与正常人相比,VTE风险在持续性,进展性和改善性组中随着蛋白尿严重性的剂量增加而增加.
- 与正常组相比,改善 (HR: 1.18),进展 (HR: 1.31) 和持久 (HR: 1.88) 蛋白尿症组的静脉瘤风险较高. 改善组的VTE风险低于持续组 (HR:0.69).
结论:
- 蛋白尿状态的变化和严重程度都与VTE发病率有显著的关联.
- 管理和改善蛋白尿可能在减轻VTE风险方面发挥关键作用.
- 这些发现强调了监测心血管风险评估中的蛋白尿动态的重要性.
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