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Updated: Jan 10, 2026

A High Throughput MHC II Binding Assay for Quantitative Analysis of Peptide Epitopes
07:59

A High Throughput MHC II Binding Assay for Quantitative Analysis of Peptide Epitopes

Published on: March 25, 2014

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对预测TCR-epitope绑定识别的计算方法的评估

Yanping Lu1,2,3, Yuyan Wang1, Meng Xu1,4,5

  • 1Guangzhou National Laboratory, Guangzhou, China.

Nature methods
|November 29, 2025
PubMed
概括

预测T细胞受体 (TCR) -表位相互作用对于免疫学至关重要. 这项研究评估了50个模型,发现数据集质量和特征多样性显著影响TCR-epitope预测准确度.

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Measuring TCR-pMHC Binding In Situ using a FRET-based Microscopy Assay19:05

Measuring TCR-pMHC Binding In Situ using a FRET-based Microscopy Assay

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相关概念视频

Conserved Binding Sites01:49

Conserved Binding Sites

Many proteins’ biological role depends on their interactions with their ligands, small molecules that bind to specific locations on the protein known as ligand-binding sites. Ligand-binding sites are often conserved among homologous proteins as these sites are critical for protein function.
Binding sites are often located in large pockets, and if their location on a protein’s surface is unknown, it can be predicted using various approaches. The energetic method computationally...
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