在老年中风幸存者中,流感疫苗接种和缺血性中风风险降低:一项具有负控验证的回顾性队列研究
Tianchi Yang1, Hanwen Yang2, Tianshu Zhou3
1Institute of Immunization and Prevention, Ningbo Municipal Center for Disease Control and Prevention, Ningbo, Zhejiang, China.
BMC geriatrics
|November 29, 2025
概括
接种流感疫苗可以降低老年幸存者的复发性缺血性中风风险. 这项研究表明了潜在的非特异性预防益处,需要进一步调查.
科学领域:
- 老年学是一门学科.
- 神经学 神经学
- 流行病学 流行病学
背景情况:
- 脑卒中是老年人残疾和死亡的主要原因,经常复发.
- 有限的研究存在于流感疫苗接种对老年幸存者中风复发的保护作用.
- 由于中风复发率很高,因此需要制定策略,以减轻这一脆弱人群的风险.
研究的目的:
- 调查流感疫苗接种与老年中风幸存者中风复发风险之间的关联.
- 评估流感疫苗接种是否在这个人口群体中提供对随后的中风事件的保护作用.
- 探索对缺血性与出血性中风的保护的潜在差异.
主要方法:
- 使用宁波区域健康信息平台进行的回顾性队列研究.
- 包括65岁以上的成年人,先前有中风病史.
- 分析了2021-2022赛季期间的流感疫苗接种作为暴露,并追踪到2022年7月.
主要成果:
- 在老年中风幸存者中,流感疫苗接种与缺血性中风风险降低有关 (aHR:0.90,95%CI:0.85-0.95).
- 疫苗接种和出血性中风风险之间没有发现显著的关联 (aHR:0.89,95%CI:0.76-1.05).
- 接种疫苗对心脏病 (aHR:0.74) 和非心脏病性中风 (aHR:0.93) 产生保护作用.
结论:
- 在老年幸存者中,流感疫苗接种与缺血性中风的风险较低有关,无论心脏病原因因素如何.
- 研究结果表明,接种流感疫苗的潜在非特异性预防益处.
- 需要进一步的随机试验来确认因果关系,并指导中风幸存者的临床实践.
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