压力高血糖比率与老年手术患者的妄想风险之间的关联:一项回顾性队列研究
Fengwei Yao1, Hongyan Zhao2, Lei Liu1
1Department of Gastrointestinal Surgery, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei, 442000, P. R. China.
BMC geriatrics
|November 29, 2025
概括
压力高血糖比率 (SHR) 与老年手术ICU患者 Delirium 的风险更高有关. 这种血糖标记可能有助于早期妄风险分层.
科学领域:
- 关键护理医学 关键护理医学
- 老年医学 老年医学
- 内分泌学 在内分泌学.
背景情况:
- 压力高血糖比率 (SHR) 是重症监护机构中新兴的血糖标志物.
- 在老年手术和创伤ICU患者中,SHR和妄之间的关联尚未得到充分理解.
- 早期识别妄风险对于改善患者的治疗结果至关重要.
研究的目的:
- 调查SHR与老年ICU患者痴呆症发病率之间的关联.
- 探索SHR作为手术和创伤ICU人群中妄想的预测因素的潜力.
- 为早期狂妄症风险分层在重症监护中的策略提供信息.
主要方法:
- 使用MIMIC-IV数据库对1111名因手术或创伤而入院的老年ICU患者 (≥65岁) 进行了回顾性队列研究.
- 以入院葡萄糖/估计平均葡萄糖 (HbA1c) 计算的SHR;使用CAM-ICU识别的妄.
- 使用多变量逻辑回归,受限立方线 (RCS) 分析和倾向得分匹配 (PSM).
主要成果:
- 在研究队列中,31.1%的人患有 Delirium.
- 较高的SHR四分位数独立地与 Delirium 的几率增加有关 (Q4 与 Q1 调整的 OR = 2.79).
- 在SHR和妄之间观察到非线性关系,具有有限的辨别能力 (AUC = 0.625).
结论:
- 在老年外科ICU患者中,SHR与妄独立相关.
- 在这个人群中,SHR显示出作为妄风险分层的工具的潜力.
- 需要进一步的前性研究来验证这些发现.
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