肠道甲素过度生长及其对儿童胃肠道疾病的影响:一项回顾性研究
Runjie Wang1,2,3, Ruixue Wang1,2,3, Yongmei Xiao1,2,3
1Department of Gastroenterology, Hepatology, and Nutrition, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
BMC gastroenterology
|November 29, 2025
概括
肠道甲素过度生长 (IMO) 在患有肠道问题,特别是功能性肠道疾病的儿童中很常见. IMO阳性儿童的腹较少,乳腺小较多,学龄儿童的发病率更高.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 微生物组研究 微生物组研究
- 功能性胃肠道疾病 功能性胃肠道疾病
背景情况:
- 肠道甲素过度生长 (IMO) 越来越多地与儿科胃肠道 (GI) 症状有关.
- 了解儿科IMO的临床和内镜形状对于诊断和管理至关重要.
研究的目的:
- 调查诊断为IMO的儿科患者的临床特征和内镜发现.
- 为了比较IMO阳性和IMO阴性儿童之间的这些特征.
主要方法:
- 从2021年9月到2022年11月,对124名患有胃肠道症状的儿童进行了回顾性分析.
- 基于乳糖甲呼吸测试 (LBT) 的IMO阳性/负性分组分层.
- 对102名接受胃镜检查/结肠镜检查的患者的临床数据和内镜/组织病理学特征的分析.
主要成果:
- 在63.7% (79/124) 的患有胃肠道症状的儿童中发现了IMO阳性.
- 具有IMO阳性儿童的腹发病率较低 (P<0.05) 和末端状状形形发病率较高 (P<0.05).
- 在功能性胃肠道疾病 (FGID) 患者中 (n=70),68.6%是IMO阳性,在学龄儿童中患病率更高 (P<0.05).
结论:
- IMO在患有胃肠道症状的儿童中普遍存在,特别是FGID.
- IMO阳性和阴性儿科患者之间存在临床和内镜差异.
- 年龄是FGID儿科人口中IMO患病率的一个重要因素.
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