高近视的独特肝功能:与近视性黄斑变性相关联
Yujun Pei1,2,3,4, Jiaqi Meng2,3,4, Wenwen He2,3,4
1School of Health Science and Engineering, University of Shanghai for Science & Technology, 516 Jungong Road, Shanghai, 200093, China.
BMC ophthalmology
|November 29, 2025
概括
这项研究发现,近视性斑点退化症 (MMD) 的高度近视患者的血清GGT较低. 肝功能测试,特别是GGT,可能有助于诊断高近视患者的MMD.
科学领域:
- 眼科医生 眼科 眼科
- 临床生物化学 临床生物化学
背景情况:
- 高近视是视力威胁并发症的重要危险因素.
- 近视性黄斑变性 (MMD) 是高近视患者视力损伤的主要原因.
- 了解MMD相关的生物标志物对于早期检测和管理至关重要.
研究的目的:
- 为了研究高近视患者的肝功能和脂质概况.
- 确定肝功能/脂质指数与近视性黄斑变性 (MMD) 之间的关联.
- 评估肝功能指数作为MMD的诊断指标的潜力.
主要方法:
- 横截面研究比较了995名视患者和805名高度近视患者.
- 使用生物化学分析仪测量血清肝功能和脂质指数.
- 基于超广场底部摄影的MMD分类 (META-PM分类).
- 机器学习模型开发用于使用肝功能指数预测MMD.
主要成果:
- 高度近视的患者表现出较低的白蛋白,性酸盐酶,谷氨基酸酶和甘油三水平,与emmetropes相比.
- 在高近视组中观察到高密度脂蛋白胆固醇和阿波脂蛋白-A的较高水平.
- 血清GGT和ALT水平在MMD类别之间存在显著差异.
- 使用GGT的机器学习模型实现了MMD预测的AUC为0.735;多重肝功能指数将AUC提高到0.803.
结论:
- 肝功能标志物和MMD严重程度之间存在密切关联.
- 血清GGT可以作为一个潜在的MMD诊断指标在高度近视的个体.
- 肝功能指数显示出预测高近视期MMD的前景.
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