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Updated: Jan 10, 2026

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对新生儿腹腔内出血的发育阶段依赖的转录基因反应.

Elizabeth Wallace-Anthony1,2, Miriam Zamorano3,4, Hemendra J Vekaria3

  • 1Bioinformatics Core, Department of Neuroscience, Medical University of South Carolina, Charleston, SC, 29425, USA.

Journal of neuroinflammation
|November 29, 2025
PubMed
概括

新生儿腹腔内出血 (IVH) 反应因大脑发育阶段而异. 晚期早产大脑对IVH表现出更强烈的炎症反应,这表明神经免疫反应的关键发育时间.

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Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
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