时钟基因之间的关联 抑郁症和肥胖的多基因风险评分 在肥胖负担很高的人群中
Hadil Adnan Abdulkader1, Maha Al-Asmakh1,2, Zumin Shi3
1Department of Biomedical Science, College of Health Sciences, QU Health, Qatar University, P.O. Box 2713, Doha, Qatar.
Nutrition & metabolism
|November 29, 2025
概括
抑郁症的遗传风险得分较高与卡塔尔成年人肥胖风险增加有关. 这种关联特别明显与某些饮食模式,表明基因-饮食相互作用影响肥胖.
科学领域:
- 遗传学和公共卫生
- 代谢障碍 研究 研究 研究 代谢障碍
- 时代生物学与疾病
背景情况:
- 扰乱昼夜节律与代谢障碍和抑郁症有关.
- 肥胖和抑郁症经常同时发生,可能是由于共同的遗传因素.
- 调查与肥胖相关的抑郁症遗传倾向至关重要.
研究的目的:
- 检查卡塔尔成年人抑郁症和肥胖症的时钟基因多基因风险评分 (PRS) 之间的关联.
- 探索关于肥胖的PRS和生活方式因素 (饮食,吸烟,身体活动) 之间的潜在相互作用.
主要方法:
- 来自卡塔尔生物银行研究的6000名卡塔尔成年人的横截面研究.
- 在18个时钟基因中使用185个单核酸多态 (SNP) 开发了PRS.
- 多变量后勤回归模型评估了PRS,生活方式因素和肥胖之间的关联.
主要成果:
- 在研究人口中,肥胖率为42.9%.
- 在时钟基因PRS和肥胖之间发现了积极的关联 (OR1.26,最高PRS四分位数的95%CI为1.08-1.39).
- 观察到PRS与饮食模式 (混合饮食,甜食/快餐,现代早餐) 和与肥胖有关的生活方式因素 (吸烟,体力活动) 之间存在显著的相互作用.
结论:
- 时钟基因PRS与卡塔尔成年人肥胖有积极的关联.
- 饮食模式与肥胖相关的时钟基因PRS显著相互作用.
- 这些发现强调了遗传倾向和生活方式在肥胖发展中的相互作用.
更多相关视频
04:33Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression
Published on: April 26, 2024
1.2K
03:05Influence of Emotional Factors on the Efficacy of Acupuncture Treatment for Overweight Complicated with Hyperlipidemia: A Retrospective Cohort Study
Published on: November 21, 2025
456
相关概念视频
Human Genetics
1.4K
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
The complex relationship between genetics and psychology is observable through common biological components such...
1.4K
Polygenic Traits
68.8K
When more than one gene is responsible for a given phenotype, the trait is considered polygenic. Human height is a polygenic trait. Studies have uncovered hundreds of loci that influence height, and there are believed to be many more. Due to the high number of genes involved, as well as environmental and nutritional factors, height varies significantly within a given population. The distribution of height forms a bell-shaped curve, with relatively few individuals in the population at the...
68.8K
Obesity
1.1K
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
1.1K
Depressive Disorders: Etiology
415
Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
415
Genome-wide Association Studies-GWAS
15.2K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
15.2K
Circadian Rhythms and Gene Regulation
4.5K
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
4.5K
