以Bacillus为基础的益生菌的食补充剂改善了被轮状病毒挑战的断奶小猪的肠道健康
Fengyu Xiang1, Heng Yang1, Xiangqi Fan1
1Animal Nutrition Institute, Sichuan Agricultural University, Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Key Laboratory of Animal Disease-Resistant Nutrition and Feed of China Ministry of Agriculture and Rural Affairs, Key Laboratory of Animal Disease-Resistant Nutrition of Sichuan Province, Chengdu, 611130, P.R. China.
Journal of animal science and biotechnology
|November 29, 2025
概括
细菌益生菌显著改善了罗塔病毒 (RV) 挑战的小猪的肠道健康. 补充剂减少了腹,增强了肠道完整性,抗氧化能力和免疫反应,为动物健康提供了一个有前途的战略.
科学领域:
- 动物科学动物科学
- 微生物学 微生物学
- 兽医医学 兽医医学 兽医医学
背景情况:
- 细菌菌株是已知的益生菌,有可能调节动物的生理功能.
- 罗塔病毒 (RV) 感染会对小猪造成严重的肠道损伤,影响它们的健康和生产力.
研究的目的:
- 为了评估一种基于Bacillus的益生菌在减轻小猪体内由轮状病毒引起的肠道损伤方面的有效性.
- 评估益生菌对肠道形态,免疫反应,抗氧化能力和微生物群的影响.
主要方法:
- 二十四只小猪被分为两个组:基础饮食和补充Bacillus益生菌 (10^9 CFU/kg) 的饮食.
- 8天后,每个组中的一半小猪被挑战了轮状病毒 (RV);其他人接受了无菌媒介.
- 挑战后12天评估了肠道健康参数.
主要成果:
- 罗塔病毒的挑战导致腹,状粘膜损伤,增加RV抗体,降低抗氧化能力和改变免疫标志物.
- RV感染负面影响了紧密结合基因表达,亡相关的基因和乳腺微生物群.
- 细菌益生菌补充剂显著减轻了RV感染对小猪肠道健康的这些负面影响.
结论:
- 基于Bacillus的饮食益生菌补充剂有效地减少了腹,并改善了断奶小猪的肠道健康.
- 益生菌的益处与改善肠道抗氧化能力,调节性亡和有益调节肠道微生物群有关.
- 细菌益生菌代表了一种可行的策略,可以增强小猪面临轮状病毒挑战的肠道健康和弹性.
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