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Updated: Jan 10, 2026

Differentiation and Characterization of Osteoclasts from Human Induced Pluripotent Stem Cells
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Differentiation and Characterization of Osteoclasts from Human Induced Pluripotent Stem Cells

Published on: March 22, 2024

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单细胞RNA-seq分析将巨细胞中的Osm信号与异型骨化过程中的骨质分化联系起来

Jian Wang1, Jiangwei Fan2, Xiaohui Yang2

  • 1Department of Traumatic Orthopedics I, The Sixth Affiliated Hospital of Xinjiang Medical University, Urumqi, 830000, China. ansus@sina.com.

Journal of orthopaedic surgery and research
|November 29, 2025
PubMed
概括

不同类型的骨化 (HO) 涉及受伤后外宫骨的形成. 巨细胞由Spi1调节,驱动异常的原始细胞分化,为HO提供新的治疗点.

关键词:
不同类型的骨化异型化.巨细胞是一个巨细胞.中介细胞的前代细胞.单细胞转录组学 单细胞转录组学

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Isolation and Enrichment of Human Adipose-derived Stromal Cells for Enhanced Osteogenesis11:00

Isolation and Enrichment of Human Adipose-derived Stromal Cells for Enhanced Osteogenesis

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Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
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