环境温度影响阴道微生物组的组成,温度敏感的阴道微生物影响辅助生殖技术的结果
Zheng Liu1,2, Wenhao Yu3,4, Tianyong Sun5
1State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, Shandong University, Jinan, 250012, China.
Microbiome
|November 29, 2025
概括
环境温度显著影响阴道微生物群.
科学领域:
- 微生物学 微生物学
- 环境科学 环境科学
- 生殖健康 生殖健康
背景情况:
- 阴道微生物组在生殖健康中起着至关重要的作用.
- 环境因素可以影响微生物群落.
- 了解这些影响对于辅助生殖技术 (ART) 的结果至关重要.
研究的目的:
- 研究环境因素如何影响阴道微生物组的组成和结构.
- 探索环境因素,阴道微生物组和ART成功之间的相互作用.
- 为了确定与环境暴露相关的特定微生物变化.
主要方法:
- 使用阿多尼斯测试来评估33个宿主/环境变量对阴道微生物群.
- 使用分布式滞后非线性模型 (DLNM) 和Mfuzz分析.
- 应用线性混合效应模型,将环境温度与阴道微生物相关联.
主要成果:
- 环境温度成为影响阴道微生物群的关键环境因素.
- 温度升高与四种不同的微生物丰富度变化的模式相关.
- 确定了特定的温度敏感细菌,影响了微生物网络的转移.
- 胚胎移植前的阴道微生物组合与早产风险有关,早产婴儿的乳酸菌内置量较高,乳酸菌缩量较低.
结论:
- 环境温度的变化会改变阴道微生物组的结构和组成.
- 敏感于温度的阴道细菌与早产风险有关.
- 这些发现强调了环境监测在ART环境中的重要性.
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