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相关概念视频

Determination of Multiple Dosing Parameters: Loading and Maintenance Doses01:25

Determination of Multiple Dosing Parameters: Loading and Maintenance Doses

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A loading dose is an essential pharmacological strategy to rapidly achieve the target plasma drug concentration necessary for an immediate therapeutic effect. This approach is especially critical for drugs characterized by slow absorption or extended half-lives, where delaying therapeutic plasma levels could compromise treatment outcomes. By administering a loading dose, clinicians ensure a prompt onset of drug action, even for agents with complex pharmacokinetic profiles.Achieving steady-state...
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Dose Size and Dosing Frequency: Determination Methods01:21

Dose Size and Dosing Frequency: Determination Methods

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Determining the optimal dose size and dosing frequency in pharmacotherapy is crucial for achieving therapeutic effectiveness while minimizing adverse effects. This article explores the methodologies employed in determining these parameters, focusing on their significance and interplay to tailor dosing regimens.Dose Size: Dose size refers to the amount of a drug administered in a single dose. It is determined based on the drug's pharmacodynamics and pharmacokinetics properties and...
257
Dosage Regimens: Designs and Approaches01:28

Dosage Regimens: Designs and Approaches

242
Designing a dosage regimen, which refers to the manner of drug administration, is a complex process involving the selection of drug dose, route, and frequency. This process is underpinned by pharmacokinetic parameters derived from tests and population averages. These parameters are then tailored to patient-specific variables such as diagnosis, demographics, and allergy status. Once therapy commences, therapeutic response monitoring is critical and achieved through clinical and physical...
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Nursing Implementation01:15

Nursing Implementation

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Implementation is the execution of the nursing care plan developed during the planning phase.
The five steps to implementing effective nursing care include reassessing the patient, reviewing and revising the existing nursing care plan, organizing the resources and care delivery, anticipating and preventing complications, and implementing nursing interventions.
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Drug Accumulation During Multiple Dosing: Repetitive IV Injections01:21

Drug Accumulation During Multiple Dosing: Repetitive IV Injections

237
Calculating drug dosage and accumulation in multiple-dose regimens is crucial for achieving therapeutic efficacy while avoiding toxicity. This involves determining the plasma drug concentrations over time to optimize dosing schedules. The principle of superposition is fundamental in this process, allowing for the prediction of drug concentration in plasma following multiple doses based on single-dose data.The principle of superposition asserts that the plasma concentration-time curves from...
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Dosage Regimen: Individualization01:24

Dosage Regimen: Individualization

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Individualization in dosing regimens is the customization of medication doses for individual patients. Its necessity arises from the goal of maximizing therapeutic benefits while minimizing risks. This approach is pivotal because human responses to drugs can vary widely; what is effective for one person may be inadequate or excessive for another. Interpatient (intersubject) variability refers to differences in drug responses between individuals, while intrapatient (intrasubject) variability...
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相关实验视频

Updated: Jan 10, 2026

The Participant-Reported Implementation Update and Score PRIUS: A Novel Method for Capturing Implementation-Related Data Over Time
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在25个实施实例中对实施剂量的现实世界量化.

Laura Ellen Ashcraft1,2,3,4, Lindsay R Pelcher5, Connor M Warren6

  • 1Center for Health Equity Research and Promotion, Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA. lauraellen.ashcraft@pennmedicine.upenn.edu.

Implementation science communications
|November 29, 2025
PubMed
概括

实施剂量,或实施基于证据的实践 (EBP) 的努力,最多取决于具体的EBP. EBP的类型是实施剂量的最强的预测因素,而不是地点或经验.

关键词:
实施剂量 实施剂量实施跟踪 执行跟踪方法 方法 方法

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科学领域:

  • 实施科学 实施科学
  • 医疗保健管理的管理
  • 医疗保健服务研究 医疗服务研究

背景情况:

  • 衡量基于证据的实践 (EBP) 的实施努力在实施科学中至关重要.
  • 现有的方法可能对现实世界的试验来说不够务实或有前景.
  • 这项研究解决了对实施活动和剂量的实际测量需求.

研究的目的:

  • 在现实世界试验中展示实施活动的前性和务实性文档.
  • 在四个不同的EBP中量化实施剂量 (频率和时间).
  • 探索影响实施剂量变化的因素.

主要方法:

  • 一个前性的,务实的跟踪系统被开发为一种III类混合有效性-实施阶段结试验.
  • 实施剂量被量化为总时间和同步时间 (与当地实施者直接交互).
  • 多重线性回归分析了影响实施剂量的因素,包括EBP,波,地点和实施进展.

主要成果:

  • 在七个退伍军人医疗中心的四个EBP (手术暂停,TAP,CAPABLE,EMPOWER) 的25个实例中捕获了超过1,271个小时的实施活动.
  • 非同步的行政任务是最常见的,其次是同步的活动,如合作者参与和解决问题.
  • 实施的具体基于证据的实践 (EBP) 是实施剂量变化的主要驱动因素.

结论:

  • 基于证据的实践 (EBP) 的类型是需要实施剂量的明显更强的预测因素.
  • 现场特征和实施者经验并不能独立解释实施剂量的变化.
  • 这凸显了在实施规划中考虑EBP特定资源需求的重要性.