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影像化生物标志物在异常性正常压力脑水性:与症状的关联和1年的治疗结果

Colin P Galvin¹, Ben Phan¹, Leo Zekelman¹

¹Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Journal of neuroimaging : official journal of the American Society of Neuroimaging

|November 29, 2025

概括

异常性正常压力脑症 (iNPH) 成像生物标志物可以帮助预测腹腔关节 (VP) 转移手术后的结果. 特定的生物标志物与步态,尿道和便失禁症状的改善相关.

科学领域:

神经学神经学
神经外科神经外科
放射学放射学是一门学科.

背景情况:

异常性正常压力脑症 (iNPH) 是一种影响老年人的神经疾病,其特点是步态障碍,尿路功能障碍和认知能力下降.
iNPH临床症状,成像生物标志物和治疗结果之间的联系尚未完全理解,特别是在便失禁 (FI) 方面.

研究的目的:

调查iNPH临床表现和手术前成像生物标志物之间的关系.
评估这些生物标志物的预测价值,以评估脑脊液 (CSF) 通过腹腔关节 (VP) 道放置转移后的结果.
探索便失禁 (FI) 和iNPH之间的关联,以及它与成像生物标志物的关系.

主要方法:

在2015年至2023年期间,对125名iNPH患者进行了VP分流安置的回顾性审查.
收集了患者的人口统计,症状和手术后3个月和12个月的临床改善情况.
测量了手术前成像生物标志物:埃文斯指数 (EI),角 (CA),侧腔室指数的前后直径 (ALVI) 和不成比例地扩大的脑下空间水脑症得分.

主要成果:

124名患者患有步态障碍,113名尿路功能障碍,111名认知能力下降. 在24名患者中存在便失禁 (FI).
手术前的FI与较高的EI和ALVI相关. 3个月后FI的改善与更大的CA有关.
12个月后改善的步态与较小的EI和ALVI相关. 手术前的尿路症状与更高的EI相关.

结论:

在iNPH患者的手术前成像生物标志物具有诊断效用.
这些生物标志物可以预测VP转移后的CSF转移后的症状改善,提供有价值的预后信息.

关键词:

埃文斯指数埃文斯指数侧心室指数的前后直径.一个叫做Callosal的角度.便失禁便失禁便失禁便失禁便失禁异常性正常压力水脑.

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