3D打印玻尿酸在乳房切除术后放射治疗中的临床应用
Qianqian Liu1, Xuming Chen1, Zhekai Hu1
1Department of Radiation Oncology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, P. R. China.
Journal of applied clinical medical physics
|November 29, 2025
概括
与传统方法相比,3D打印的球体显著改善了适应性,并减少了乳房切除术后放射治疗中的空气隙. 这确保了更好的剂量传递,特别是对于较大的差距,改善乳腺癌患者的治疗准确性.
科学领域:
- 医学物理 医学物理
- 放射治疗技术 放射治疗技术
- 在瘤学瘤学.
背景情况:
- 精确的剂量输送在乳腺切除术后的放射治疗中至关重要.
- 患者和辐射源之间的空气间隙可能导致剂量不足.
- 传统的球体可能不完全符合患者的解剖学,造成空气隙.
研究的目的:
- 为了评估3D打印螺栓 (3DPB) 的适配精度.
- 评估3DPB对乳腺切除术后放射治疗中剂量分配的影响.
- 为了比较3DPB与常规玻尿酸 (CB) 在管理空气间隙.
主要方法:
- 圆束计算机断层扫描 (CBCT) 用于测量27名乳腺癌患者的空气隙.
- 一个CIRS胸部幻影模拟了不同大小的空气间隙的剂量效应.
- 进行了3D打印玻尿酸 (3DPB) 和传统玻尿酸 (CB) 的比较.
主要成果:
- 与CB相比,3DPB显著降低了最大和总空隙体积.
- 3DPB的平均最大间隙高度为0.53厘米,而CB的2.23厘米 (p<0.05).
- 表面皮肤区域 (SSZ),临床目标体积 (CTV) 和计划目标体积 (PTV) 的剂量减少在间隙≤2厘米时无意义,但在间隙>2厘米时更为明显.
结论:
- 3DPB提供了优越的解剖适应性,最大限度地减少了乳房切除术后放射治疗中的空气隙和剂量损失.
- 对于≤2厘米的空气间隙,CB提供了临床上可接受的剂量减弱.
- 对于差距大于2厘米,建议使用3DPB,以防止显著减少剂量并确保目标覆盖.
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