联合范围调节器和对布拉格峰质子FLASH放射治疗的点优化.
Jiayue Han1, Aoxiang Wang2, Ya-Nan Zhu3
1Department of Radiation Oncology, University of Kansas Medical Center, Kansas City, Kansas, USA.
Medical physics
|November 29, 2025
概括
一种新的联合距离调节器和点优化 (JRSO) 方法通过同时优化光束参数来改进质子FLASH (pFLASH) 放射治疗计划. 这种新的方法提高了计划质量,并扩大了pFLASH治疗的临床适用性.
科学领域:
- 医学物理 医学物理
- 辐射瘤学 辐射瘤学
- 计算生物学 计算生物学
背景情况:
- 超高剂量率 (UHDR) 辐射疗法,特别是质子FLASH (pFLASH),显示出降低风险器官 (OAR) 毒性的潜力.
- 目前的pFLASH治疗计划涉及两个步骤的过程:强度调制质子疗法 (IMPT) 计划生成,然后是患者特定范围调制器 (PSRM) 优化.
- 在pFLASH治疗中,点重量和PSRM设计之间的相互作用尚未完全理解,这可能会限制剂量计和放射生物学的益处.
研究的目的:
- 引入一个新的交替优化框架,联合距离调制器和点位优化 (JRSO),用于同时优化PSRM和点位权重.
- 通过综合优化,提高符合规范的pFLASH放射治疗的计划质量.
主要方法:
- 为同时优化开发的JRSO框架,消除了对光束点和PSRM引脚之间一对一对应的需求.
- 使用高斯函数建模的质子束扩散.
- 从IMPT衍生解决方案开始,对PSRM设计和点位权重进行代交替更新,同时遵守最小监控单位 (MMU) 等约束.
主要成果:
- 与传统方法相比,JRSO证明了优越的计划质量.
- 在一个头和子 (HN) 案例中,JRSO降低了目标功能值 (0.46至0.26),降低了最大目标剂量 (117.6%至107.1%),改善了符合指数 (0.74至0.87),并降低了ROI有效剂量 (6.50Gy至6.10Gy).
结论:
- 拟议的JRSO方法为符合规范的pFLASH放射治疗规划提供了进步.
- JRSO的性能优于传统的方法,并且可以在复杂的临床场景中扩大PSRM的适用性,包括点针错位.
- 数字结果证实了JRSO方法的稳定性和效率.
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