结直肠多分布与年龄相关:元分析
Sai Tim Yam1, Jared McLauchlan1, Andrew McCombie2
1Department of Surgery and Critical Care, University of Otago, Christchurch, New Zealand.
BJS open
|November 29, 2025
概括
年轻人 (<50岁) 显示左侧多的患病率更高. 这一发现对于定制结直肠癌查和症状调查在这个人口群体中至关重要.
科学领域:
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
- 公共卫生 公共卫生
背景情况:
- 全球早期结直肠癌 (CRC) 的增长与西方国家的下降率形成鲜明对比.
- 在年轻人群中聚分布的有限数据使查策略复杂化.
- 这一系统性审查解决了有关跨年龄组的息肉患病率的知识差距.
研究的目的:
- 系统地审查现有的关于不同年龄组中多分布的文献.
- 为了比较50岁以下的个体与50岁及以上的个体中的多位 (左结肠与右结肠).
- 为年轻患者的CRC查和症状评估提供临床实践的信息.
主要方法:
- 在主要数据库 (PubMed,Scopus等) 进行全面的文献搜索. 使用关键词"年龄"和"多重体".
- 包括英语文章,详细介绍了按年龄划分的息肉分布 (腺瘤,晚期,状状病变).
- "年轻患者"的定义是年龄在50岁以下的个人.
主要成果:
- 分析了24项符合条件的研究,其中12项被纳入了元分析.
- 年轻个体 (<50岁) 呈现75.9%的左侧息肉,而老年人 (≥50岁) 的61.9%.
- 分析证实,年轻人中左侧多的比例显著更高 (MD 0.06,CI 0.03-0.09;OR 0.77,CI 0.59-1.01).
结论:
- 50岁以下的个体表现出对左侧结肠的偏好.
- 这种分布反映了早期结直肠癌中观察到的情况.
- 这些发现需要对50岁以下出现症状的个体进行调整查和诊断方法.
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