在CRS中系统性炎症标记物和血清维生素D的诊断和预后价值
Junming Ma1, Xiaohong Chen1, Yanjie Jiang1
1Department of Otolaryngology-Head and Neck Surgery, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
系统性炎症标志物和维生素D水平预测慢性鼻炎 (CRS) 的预后. 高氨基酸与淋巴细胞比率 (ELR) 和低维生素D水平有助于预测氨基酸性CRS (ECRS).
科学领域:
- 免疫学 免疫学 免疫学
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 内分泌学 在内分泌学.
背景情况:
- 慢性鼻炎 (CRS) 是一种复杂的炎症状况.
- 预测预后和特定的亚型,如酸性CRS (ECRS) 仍然具有挑战性.
研究的目的:
- 调查系统性炎症标志物和CRS中的维生素D的预后价值.
- 使用临床和实验室因素开发ECRS的预测模型.
主要方法:
- 对1072名CRS患者和229名对照人群的回顾性分析.
- 倾向性得分匹配 (PSM) 进行可靠的比较.
- 使用了后勤和考克斯回归模型,名图,ROC曲线和卡普兰-梅尔分析.
主要成果:
- 血清25-基维生素D (25(OH) D) 降低和高氨基酸对淋巴细胞比率 (ELR) 预测ECRS.
- 糟糕的CRS预后与维生素D缺乏有关.
- 对于CRS的关键预后因素包括绝对乙素细胞计数 (EOS#),淋巴细胞百分比,血小板与淋巴细胞的比率 (PLR),血小板分布宽度 (PDW),骨炎得分和低的25...OH) D水平.
结论:
- 系统性炎症标志物和维生素D水平是CRS预后和ECRS的重要预测因素.
- 开发出来的诺姆图表在预测CRS和ECRS结果方面表现出很高的准确性.
- 这些发现可以指导临床管理和CRS患者的风险分层.
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