肠道微生物群和高血压的饮食指数之间的关联:基于NHANES的横截面研究
Yanhui Shi1, Man Zhang1, Huawei Miao1
1Department of Cardiology, Hebei Provincial Hospital of Traditional Chinese Medicine.
Journal of hypertension
|November 29, 2025
概括
肠道微生物群 (DI-GM) 的较高饮食指数与较低的高血压风险有关. 这种关联在非吸烟者和有伴侣的人群中最强,这表明个性化的饮食策略可以用于高血压管理.
科学领域:
- 微生物组研究的研究.
- 营养科学 营养科学
- 心血管健康的心血管健康
背景情况:
- 肠道微生物群在高血压的发展中起着至关重要的作用.
- 饮食模式显著影响肠道微生物的组成和功能.
- 肠道微生物群的饮食指数 (DI-GM) 与高血压风险之间的特定关系尚未得到充分证实.
研究的目的:
- 调查肠道微生物群的饮食指数 (DI-GM) 与患高血压的风险之间的关联.
- 在这个协会中探索潜在的非线性关系和人口异质性.
主要方法:
- 分析了2005-2016年国家健康和营养检查调查 (NHANES) 的11,429名参与者的数据.
- 利用加权多变量逻辑回归和限制立方线 (RCS) 模型来评估DI-GM-高血压关系.
- 进行了子组分析,以确定不同的人口和生活方式群体之间的协会变化.
主要成果:
- 更高的DI-GM得分与降低高血压风险显著相关 (OR=0.95).
- 与最低四分位数 (OR=0.79) 相比,DI-GM最高四分位数的个体患高血压的风险降低了21%.
- 这种联系在女性,年轻人,大学毕业者和从未吸烟者中更为强烈,对婚姻状况和吸烟有显著的相互作用.
结论:
- 较高的DI-GM得分与降低高血压风险有关.
- DI-GM的保护作用在非吸烟者和有伴侣的个人中最为明显.
- 未来的高血压预防和管理策略应考虑人口异质性,并纳入个性化的饮食干预措施.
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