在社区居住的老年人中开发和验证预测萨科佩尼亚的诺莫图谱
Sook Kyoung Park1, Hyuk Joo Kim2, Young-Me Lee3
1Jeonbuk National University, Jeonju, South Korea.
概括
这项研究确定了老年人肉类的关键风险因素,包括年龄,脏疾病,肥胖,不适和久坐时间. 开发了一种预测性名谱,以帮助早期识别高风险个体.
科学领域:
- 老年学是一门学科.
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 萨科佩尼亚是社区居住的老年人的重大健康问题,导致发病率和死亡率增加.
- 早期识别患有肉症风险的个体对于及时干预和管理至关重要.
- 现有的风险评估工具可能无法充分捕捉不同人群中肉症的多因素性质.
研究的目的:
- 在社区居住的老年人中识别与肉类相关的重大风险因素.
- 开发和验证一个预测性名谱来估计肉类的概率.
- 为老年人提供早期查和风险分层的实用工具.
主要方法:
- 韩国2023年全国健康和营养检查调查的横截面二次数据分析.
- 包括1836名65岁及以上的社区成年人.
- 复杂样本后勤回归分析以确定风险因素并开发名图,预测准确度由接收器操作特征曲线 (AUC) 下的区域评估.
主要成果:
- 萨科佩尼亚的重要危险因素包括年龄 (75岁以上),脏疾病,肥胖状况,不适以及久坐时间的增加.
- 随着年龄的增长,肉类的几率大大增加 (80岁以上的5.01倍) 和患有病的几率 (3.29倍).
- 开发的诺米图,包括肥胖,久坐时间,年龄,脏疾病和不舒服,AUC达到0.809,表明预测准确度很好.
结论:
- 肥胖,久坐不动,晚年,脏疾病和不舒服是影响老年人缩症风险的关键因素.
- 开发的诺米图表作为一种有价值和实用的工具,用于早期识别社区居住的老年人,他们面临高风险的肉症.
- 建议进行进一步的研究,包括纵向数据和客观测量,以完善预测模型和临床验证.
相关概念视频
Dosage Regimen Designs: Nomograms and Tabulations
161
Nomograms and tabulations are vital tools used by clinicians to design accurate and individualized dosage regimens. These instruments provide a straightforward method for adjusting dosages based on individual patient characteristics, including age, weight, and physiological condition. The foundation of a drug's nomogram is population pharmacokinetic data collected and analyzed using specific models. This data simplifies complex equations, presenting them diagrammatically or tabularly for easy...
161
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion
221
In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
221
Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration
174
Glomerular filtration rate (GFR) can be estimated from serum creatinine using the modification of diet in renal disease (MDRD) formula or the chronic kidney disease–epidemiology collaboration (CKD–EPI) equation. Both methods are widely used in clinical practice to assess kidney function and guide treatment decisions.The MDRD equation does not require weight or height measurements and is normalized to the body surface area of 1.73 m², considered the average adult surface area.
174
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution
216
Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...
216


