双极性障碍作为帕金森病的长期风险因素:全国一项病例控制研究
Elina Jaakkola1,2,3, Marjaana Koponen4, Valtteri Kaasinen1,2
1Clinical Neurosciences, University of Turku, Turku, Finland.
Movement disorders : official journal of the Movement Disorder Society
|November 29, 2025
概括
双极性障碍 (BD) 与帕金森病 (PD) 的风险显著增加有关,甚至在PD发病前几十年. 这表明BD可能表明对发展PD的长期脆弱性.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 流行病学 流行病学
背景情况:
- 以前的研究表明,双相情感障碍 (BD) 和帕金森病 (PD) 之间存在联系.
- 长期的时间关系和BD和PD风险之间的诊断持续时间的影响仍然不清楚.
研究的目的:
- 在延长的时间窗口中调查BD和PD之间的关联.
- 为了检查PD风险在PD诊断之前的各种暴露持续时间,长达35年.
主要方法:
- 在芬兰进行了一项全国性的,基于登记的,嵌套的病例控制研究.
- 包括22,189名PD患者和148,009名匹配对照,分析了自1972年以来的BD诊断.
- 条件后勤回归评估了BD-PD与延迟长达35年的关联,重点关注8年的延迟.
主要成果:
- 在0.87%的PD患者中,BD诊断先于PD诊断,而对照组0.34%.
- 随着20年的滞后,观察到PD风险升高,即使在30年后也显示出趋势.
- 诊断BD与PD的相对风险增加两倍以上 (aOR 2.32,95% CI 1.85-2.91) 与8年滞后相关.
结论:
- 双极性障碍与帕金森病的风险增加有显著关联,在PD发病前几十年可检测到.
- 研究结果表明,BD可能代表了长期对PD的脆弱性,而不仅仅是前兆状态.
- 对BD和PD的共同病理生理机制进行进一步的研究是有必要的.
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