多药组合的多轨迹和根据脆弱状态的临床结果:一个纵向队列研究
Liang-Yi Lin1, Fei-Yuan Hsiao1,2,3, Shih-Tsung Huang4,5
1Graduate Institute of Clinical Pharmacy, College of Medicine, National Taiwan University, Taipei City, Taiwan.
Age and ageing
|November 29, 2025
概括
老年人中的多药模式显示,主要的症状治疗药物增加了死亡和住院的风险. 这些风险通常随着脆弱性增加而减少,除了与骨折相关的住院治疗外.
科学领域:
- 老年学是一门学科.
- 药理学 药理学是指药理学的学科.
- 公共卫生 公共卫生
背景情况:
- 多药性在老年人中很常见,但它对基于药物成分和虚弱状态的临床结果的影响尚不清楚.
- 鉴定多药组合的截然不同的纵向模式及其相关的临床结果,按脆弱分层,对于这个人口群体至关重要.
研究的目的:
- 为了确定老年人中多药成分的明显纵向模式.
- 评估这些多药模式与随后的临床结果之间的关联,包括死亡率和住院治疗,按脆弱状态分层.
主要方法:
- 利用台湾国家健康保险研究数据库对大量老年人进行了研究.
- 采用基于小组的多轨迹建模来识别多药学模式.
- 应用了考克斯的比例危险模型来分析6年不良结果的风险.
主要成果:
- 确定了三个主要的多药模式:心脏代谢主导,症状治疗主导和结合心脏代谢/症状治疗主导.
- 与心脏代谢主导模式相比,症状治疗主导模式与所有原因死亡率,所有原因住院和无计划住院风险显著增加.
- 与症状治疗模式相关的风险增加通常随着脆弱性增加而减弱,除了骨折特定的住院治疗外.
结论:
- 由症状治疗主导的多药模式与老年人不良临床结果的风险增加有关.
- 这些药物模式与不良结果之间的关联通常随着脆弱性增加而减少,但骨折风险仍然很高.
- 调查结果强调了在老年人多药店管理中考虑药物成分的重要性,特别是在脆弱方面.
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