自闭症中的肠-大脑轴:炎症机制,分子洞察力和新兴的基于微生物组的疗法
Helal F Hetta1, Fawaz E Alanazi2, Saleh F Alqifari3
1Division of Microbiology, Immunology and Biotechnology, Department of Natural Products and Alternative Medicine, Faculty of Pharmacy, University of Tabuk, 71491, Tabuk, Saudi Arabia.
Molecular neurobiology
|November 29, 2025
概括
自闭症谱系障碍 (ASD) 与肠道微生物组失衡有关. 诸如益生菌和饮食等干预措施在改善自闭症和肠道症状方面表现有前途.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 遗传学 是一个遗传学.
背景情况:
- 自闭症谱系障碍 (ASD) 是一种复杂的神经发育状况,具有遗传,环境和微生物因素.
- 肠-大脑轴在ASD中起着关键作用,肠道微生物群的改变与神经发育和行为问题有关.
- 患有自闭症的人经常表现出肠道失调,其特点是微生物失衡,多样性减少和肠道透性增加.
研究的目的:
- 审查有关ASD微生物组变化的最新证据.
- 探索将肠道失调与ASD中神经发育联系在一起的机制.
- 讨论基于微生物组的干预措施对ASD的治疗潜力.
主要方法:
- 关于ASD和肠道微生物群的最新研究的文献综述.
- 分析涉及肠道失调,炎症,神经递质合成和代谢功能障碍的机制.
- 评估针对肠道微生物组的新兴疗法.
主要成果:
- 肠道失调,包括改变的微生物组成和减少的多样性,经常在患有自闭症的个体中观察到.
- 肠道失调有助于全身炎症,改变神经递质合成和代谢功能障碍,影响大脑功能.
- 治疗策略如益生菌,益生菌,饮食改变和便微生物群移植 (FMT) 显示出管理肠道和ASD症状的潜力.
结论:
- 肠道微生物组是ASD病理生理学的重要因素.
- 准肠道微生物组为ASD管理提供了有希望的治疗途径.
- 对ASD肠-大脑轴的进一步研究可以导致新的治疗策略.
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