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在前肢和后肢之间肌肉内注射后,在罗鱼中比较ceftazidime的药理动力学

Rathanak Sorn¹, Seavchou Laut¹, Narumol Klangkaew¹

¹Department of Pharmacology, Faculty of Veterinary Medicine, Kasetsart University, Bangkok, 10900, Thailand.

Veterinary research communications

|November 29, 2025

概括

塞法胺 (CAZ) 的药理动力学在罗鱼中显示出快速吸收和高生物可用性,无论注射地点如何. 这表明,在鱼中,可能有针对格兰氏阴性病原体的有效剂量.

科学领域:

兽医药理学兽医药理学
类学类学类学类学
抗微生物药物的药理动力学

背景情况:

塞法胺 (CAZ) 是对格兰氏阴性感染的关键抗生素.
了解爬行动物的药物药理动力学对于有效治疗至关重要.
罗鱼 (Crocodylus siamensis) 在药物管理方面具有独特的生理考虑.

研究的目的:

为了评估塞夫塔齐 (CAZ) 在鱼中的药理动力学.
为了比较前肢和后肢肌肉内注射后的CAZ吸收和排放.
为了确定鱼中最佳剂量方案的潜力.

主要方法:

单次肌肉内注射塞夫塔齐迪姆 (20 mg/kg) 进入鱼前肢或后肢.
药物动力学参数分析包括Cmax,Tmax,AUC,t1/2λz,Cl和生物可用性.
在注射部位之间对药物动力学概况的统计比较.

主要成果:

前肢和后肢注射部位之间的药理学参数没有显著差异 (p > 0.05).
快速的CAZ吸收 (Tmax中位数=0.5小时) 和高的生物利用率 (前肢:90.35%,后肢:86.12%).
延长的排泄半衰期 (t1/2λz高达49.02小时) 和低清除率 (Cl高达4.42毫升/小时/公斤) 表明不频繁的剂量可行性.

结论:

塞法胺在罗鱼中表现出有利的药理动力学,无论注射地点如何.
观察到的药物动力学特征支持潜在的治疗疗效对敏感的阴性病原体,包括Pseudomonas aeruginosa.
特定物种的药理动力学数据对于在鱼医学中开发有针对性的抗微生物策略至关重要.

关键词:

塞夫塔齐迪姆 (Ceftazidime) 是一种一种前肢的前肢是什么意思前肢的前肢是什么意思后肢后肢是一个后肢.药理动力学药理动力学门系统是脏的门户系统.姆淡水鱼 - - 姆淡水鱼

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