从Panax Ginseng中分离的Lacticaseibacillus Casei KGC1201通过调节肠道环境来缓解硫酸诱导的大肠炎
Ji-Soo Jeong1, Je-Won Ko1, Su-Yeon Yoo2
1College of Veterinary Medicine (BK21 FOUR Program), Chungnam National University, 99 Daehak-ro, Daejeon, 34131, Republic of Korea.
Probiotics and antimicrobial proteins
|November 29, 2025
概括
帕纳克斯人参中的益生菌Lacticaseibacillus casei KGC1201在小鼠中有效降低了结肠炎症状. 这种有益的肠道细菌还通过激活关键信号通路来促进肠道的修复.
科学领域:
- 胃肠病学 胃肠病学
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
背景情况:
- 肠道微生物群失调是炎症性肠道疾病 (IBD) 发病的一个关键因素.
- 益生菌通过调节肠道微生物群来提供治疗潜力.
研究的目的:
- 在小鼠模型中研究Lacticaseibacillus casei KGC1201对硫酸 (DSS) 诱导的大肠炎的治疗作用.
- 评估L. casei KGC1201对肠道微生物群组成和肠道上皮再生的影响.
主要方法:
- 在DSS挑战之前和期间,向小鼠口服L. casei KGC1201 (206和412毫克/公斤).
- 通过体重,便一致性,结肠长度和结肠组织病理学来评估结肠炎的严重程度.
- 使用16S rRNA测序对便微生物群组成的分析.
主要成果:
- L. casei KGC1201的使用显著缓解了结肠炎症状,包括体重减轻和腹,并减少了结肠缩短.
- 益生菌调节肠道微生物组成,促进有益的细菌和相关的代谢途径.
- 肠上皮质再生得到增强,Wnt3a/β-catenin信号通路的激活证明了这一点.
结论:
- 来自人参的L. casei KGC1201在DSS诱导的小鼠模型中显示出显著的抗结肠炎作用.
- 这种益生菌有望缓解IBD症状,并通过微生物群调节和增强肠道修复来支持肠道健康.
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