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在白风患者中,亡,炎症和与氧化/化压力相关的miRNA表达

Nuray Üremiş¹, Ergül Belge Kurutaş², Perihan Öztürk³

¹Department of Medical Biochemistry, Medical Faculty, Kahramanmaras Sutcu Imam University, Kahramanmaras, Turkey. nurayuremis@gmail.com.

Irish journal of medical science

|November 29, 2025

概括

Vitiligo 病原体包括改变的微RNA (miRNA) 水平和增加的氧化应激. 这项研究发现了与亡和黑色素发生有关的miRNAs的显著变化,以及白风患者氧化应激生物标志物升高.

科学领域:

皮肤病学皮肤病学
分子生物学分子生物学
生物化学生物化学

背景情况:

Vitiligo 病变与黑色素细胞死亡有关,可能是由于反应性氧和物种 (ROS / RNS).
微RNAs (miRNAs) 与白风中氧化/化应激之间的确切相互作用尚不清楚.

研究的目的:

研究参与氧化应激,亡和白病中黑色素发生的miRNAs的作用.
为了将这些miRNA变化与氧化和化应激的血生物标志物相关联.

主要方法:

使用定量实时PCR测量30名白风患者和30名健康对照患者血中34个miRNAs的表达.
评估了氧化/化应激标记的血和红细胞水平,包括恶性甲酸 (MDA),氧化 (NO),3-甲酸铁 (3-NT),酶 (CAT) 和超氧化变酶 (SOD).

主要成果:

与对照组相比,在白风患者中,34个miRNA中的29个的表达水平发生了显著的改变 (上调或下调).
特定的miRNAs如miR-34a-5p,miR-146a-5p和miR-223-3p显示了统计学上显著的变化 (p < 0.001).
Vitiligo 患者的血MDA,NO 和 3-NT 含量显著增加,SOD 和 CAT 活性降低.

结论:

与黑色素细胞亡,炎症,氧化应激和黑色素发生相关的miRNA表达的显著变化与白风病原发生有关.
氧化和化应激标记的增加进一步支持它们在疾病生理病理学中的关键作用.

关键词:

抗氧化剂是一种抗氧化剂.细胞灭亡 (apoptosis) 是一种死亡的过程.亚酸性压力是一种压力.氧化应激是一种氧化应激.脊髓灰质炎 (Vitiligo) 是一种疾病.这是一个微型RNA.

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