数字彩色视觉测试揭示了多发性硬化症中广泛存在的形功能障碍,独立于视神经炎
Yehuda Warszawer1,2, Aviva Gal2, Terrace Waggoner3,4
1Gray Faculty of Medical and Health Sciences, Tel-Aviv University, Tel-Aviv, Israel.
European neurology
|November 29, 2025
概括
彩色视力缺陷 (CVD) 在复发性复发性多发性硬化症 (RRMS) 患者中很常见,即使没有视神经炎 (ON). 这表明MS患者的广泛,亚临床光学通路损伤.
科学领域:
- 眼科医生 眼科 眼科
- 神经学 神经学
- 神经科学是一个神经科学.
背景情况:
- 复发性复发性多发性硬化症 (RRMS) 可以影响视觉通路.
- 视神经炎 (ON) 是已知的并发症,但亚临床损伤的理解较少.
- 彩色视觉缺陷 (CVD) 可能表明光通路功能障碍.
研究的目的:
- 在RRMS患者中调查心血管疾病的患病率和模式.
- 确定心血管疾病是否可以作为亚临床光通路损伤的标志物.
- 在有和没有ON病史的眼睛中比较心血管疾病.
主要方法:
- 在345名RRMS患者中使用Waggoner计算机化色彩视觉测试评估了色彩视觉.
- 选了质子,双,三和复合CVD,分级严重程度.
- 使用多变量逻辑回归分析差异,控制临床因素.
主要成果:
- 在76.0%的ON受影响的眼睛中发现心血管疾病,在65.1%的同眼睛中发现心血管疾病,在没有ON史的眼睛中发现心血管疾病.
- ON受影响的眼睛患重症心血管疾病的几率更高; 其他眼睛患中度心血管疾病的几率更高.
- 复合CVD是最常见的 (57.7%);三缺乏是最常见的纯型 (39.9%).
结论:
- 心血管疾病在RRMS中非常普遍,无论临床ON病史如何.
- 结果表明MS的光学通路损伤是分散的,亚临床的.
- 心血管疾病评估可能有助于识别MS中亚临床功能障碍.
相关概念视频
Color Vision
1.3K
Color perception begins in the retina, the light-sensitive layer at the back of the eye. Two main theories explain how colors are seen: the trichromatic theory and the opponent-process theory. The trichromatic theory, proposed by Thomas Young in 1802 and extended by Hermann von Helmholtz in 1852, suggests that color vision is based on three types of cone receptors in the retina. These cones are sensitive to different but overlapping ranges of wavelengths corresponding to red, blue, and green.
1.3K
Photoreceptors and Visual Pathways
8.6K
At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category,...
8.6K
Anatomy of the Eyeball
9.3K
The eye is a spherical, hollow structure composed of three tissue layers. The outer layer — the fibrous tunic, comprises the sclera — a white structure — and the cornea, which is transparent. The sclera encompasses some of the ocular surface, most of which is not visible. However, the 'white of the eye' is distinctively visible in humans compared to other species. The cornea, a clear covering at the front of the eye, enables light penetration. The eye's middle...
9.3K


