肝硬化中非肝癌的患病率和危险因素:一个横截面研究
Di Sun1,2, Liyan Dong1,3, Yue Sun1,2
1Department of Gastroenterology, General Hospital of Northern Theater Command, Shenyang, China.
肝硬化患者患非肝癌 (NHC) 的风险更高. 吸烟与增加NHC风险有关,而脑病和心脏病可能会降低这些患者的NHC风险.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 肝硬化患者面临非肝癌 (NHC) 的风险增加,需要对患病率和风险因素进行研究.
- NHC显著恶化了患者的结果,强调了对肝硬化患者群体进行有针对性的调查的需要.
研究的目的:
- 确定诊断为肝硬化病的患者中NHC的患病率.
- 确定与肝硬化患者NHC发展相关的风险因素.
主要方法:
- 在2010年1月至2014年6月期间入院的2509名肝硬化患者的回顾性查.
- 经年龄和性别调整后的物流回归分析,以评估NHC的风险因素.
- 对已识别的风险因素进行调整的赔率比率 (aOR) 和95%置信区间 (CI) 的计算.
主要成果:
- 在纳入患者中,NHC患病率为6.22%,原发性肝癌 (PLC) 为22.20%.
- 吸烟史显著增加了NHC风险 (aOR = 1.994;P = 0.005). 吸烟史显著增加了NHC风险 (aOR = 1.994;P = 0.005).
- 脑病史 (aOR = 0.344;P = 0.014) 和心脏病 (aOR = 0.300;P < 0.001) 与较低的NHC风险相关.
结论:
- 吸烟是患有肝硬化患者NHC的潜在危险因素.
- 脑病和心脏病可能与这种患者群体中NHC的可能性降低有关.
- 诸如HBV,HCV和滥用酒精等病因与肝硬化患者的NHC风险没有显著联系.
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