接种COVID-19疫苗后心脏不良事件的个人的再接种疫苗:加拿大免疫研究网络的一项研究
Pierre-Philippe Piché-Renaud1, C Arianne Buchan2, Catherine Burton3
1Division of Infectious Diseases, The Hospital for Sick Children, Toronto, ON, Canada; Department of Pediatrics, University of Toronto, Toronto, ON, Canada; Child Health Evaluative Sciences, SickKids Research Institute, Toronto, ON, Canada.
Vaccine
|November 29, 2025
概括
对于胸部疼痛的人来说,COVID-19 mRNA疫苗的再接种是可能的,但建议在接种疫苗后对先前被诊断为心肌炎的成年人进行谨慎.
科学领域:
- 心脏病学 心脏病学
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
背景情况:
- 肌心炎和心膜炎是与COVID-19 mRNA疫苗相关的免疫接种 (AEFI) 后的罕见不良事件.
- 对于先前患有心脏AEFI的个人进行再接种疫苗的安全性数据有限.
研究的目的:
- 在有心脏AEFI病史的参与者中评估COVID-19 mRNA疫苗再接种疫苗的结果.
- 评估再接种疫苗后的安全性和症状复发情况.
主要方法:
- 从特殊免疫接种诊所网络数据库 (114名参与者) 的数据分析.
- 使用布莱顿协作案例定义 (BCCD) 进行心脏AEFI的分类.
- 再接种疫苗后长达42天的随访,以监测AEFI复发.
主要成果:
- 16名参与者接受了再接种疫苗:2名患有心肌炎,2名患有心肌炎,2名患有心周炎,10名患有胸痛或其他心脏病诊断.
- 四名成年人出现了复发症状:2人以前有胸痛,1人患有心膜炎和并发症,1人患有心肌炎需要住院治疗.
- 38.0%需要额外剂量的参与者被建议重新接种疫苗.
结论:
- 对于胸痛不符合心肌炎标准的个体,可以考虑进行COVID-19 mRNA再接种.
- 由于潜在的症状复发,建议在COVID-19后的mRNA疫苗接种后有心肌炎病史的成年人谨慎使用.
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