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精神分裂症的认知在疾病的各个阶段:一个系统的审查和元分析
J Hunter Howie1, Calvary R Fielden1, Melisa V Rempfer1
1Department of Psychology, The University of Kansas, Fraser Hall, 1415 Jayhawk Blvd., Lawrence, KS 66045, USA.
Psychiatry research
|November 29, 2025
概括
认知衰退从精神分裂症的早期阶段发展到所有领域的第一发精神病. 晚期的疾病阶段显示出最小的认知衰退,除了语言,在精神分裂症谱系障碍.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 认知心理学 认知心理学
背景情况:
- 认知缺陷是精神分裂症谱系障碍的核心特征,影响功能结果.
- 了解精神分裂症认知功能寿命轨迹对于有效的治疗计划至关重要.
研究的目的:
- 系统地审查和元分析精神分裂症不同疾病阶段的认知变化.
- 识别受影响的特定认知领域以及随着时间的推移下降的程度.
主要方法:
- 根据PRISMA指南进行了系统审查和元分析.
- 包括在2025年7月1日之前发表的69项研究.
- 认知能力被评估在六个领域:复杂的注意力,执行功能,感知运动功能,语言,学习和记忆,以及社会认知.
主要成果:
- 在所有领域观察到从前兆阶段到第一次情节精神病 (FEP) 的轻微到中度的认知衰退.
- 从FEP到多次发作/慢性 (ME) 疾病的下降值可以忽略到很小,语言是例外.
- 这些发现突出了精神分裂症的整个过程中认知障碍的渐进模式.
结论:
- 认知功能在早期精神分裂症中显著下降,晚期精神分裂症的变化更为适度.
- 这些发现强调了早期干预精神分裂症谱系障碍的认知症状的重要性.
- 需要进一步的研究来探索认知进展的细微差别,并告知有针对性的治疗策略.
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