通过TLR2/TGF-β2信号通路调节突巨细胞极化,CXCL9-预条件的BMSC减轻了老鼠创伤后关节炎的发生

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Hao Li1, Tao Wang2, Fanchao Li1

  • 1Department of Emergency, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou Province, China; Emergency Medicine Laboratory, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou Province, China; School of Clinical Medicine, Guizhou Medical University, Guiyang, Guizhou Province, China.

International immunopharmacology
|November 29, 2025
PubMed
概括

在CXCL9的预处理中,它增强了介质干细胞 (MSC),以减少创伤后关节炎 (PTOA) 的炎症. 这些修改后的MSCs促进巨细胞M2极化,有效地减轻PTOA在老鼠模型中的进展.

关键词:
这就是BMSCs.在CXCL9中使用.巨细胞的两极分化美国PTOAA

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