子宫内膜异位症和子宫内膜异位症之间的关联:系统性审查和元分析
Alexander Fiore1, Maíra Casalechi1, Edgardo Somigliana2
1Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Reproductive biomedicine online
|November 29, 2025
概括
子宫内膜异位症和子宫内膜异位体的息肉经常同时出现,增加了这两种疾病的风险. 这种关联在患有不孕症的女性中尤为明显,突出了需要改进检测和治疗策略的需要.
科学领域:
- 妇科 妇科 妇科 妇科
- 生殖医学 生殖医学
- 在瘤学瘤学.
背景情况:
- 子宫内膜异位症和子宫内膜聚是常见的雌激素依赖性妇科疾病.
- 这些情况往往并存,但它们的联合流行率和相互风险尚未得到充分确立.
研究的目的:
- 综合现有的关于子宫内膜异位体在子宫内膜异位症患者女性中患病率的数据,反之亦然.
- 量化子宫内膜异位症和子宫内膜聚体之间的关联.
主要方法:
- 在PubMed,Embase和Scopus的系统文献搜索到2024年10月.
- 包括报告流行数据的观察性研究.
- 使用随机效应模型来计算聚合比例和风险比率 (RR) 的元分析.
- 使用纽卡斯尔-太华尺度和GRADE指南评估的偏见风险和证据确定性.
主要成果:
- 包括22项涉及10,928名患者的研究.
- 患有子宫内膜异位症的女性显示子宫内膜异位症的风险增加了2.18倍 (RR 2.18,95% CI 1.58-3.00).
- 患有子宫内膜息肉的女性患子宫内膜异位症的风险增加了2.05倍 (RR 2.05,95% CI 1.61-2.62).
- 观察到一种剂量与反应的关系,较高的子宫内膜异位症阶段与增加的息肉风险有关.
- 这种联系在患有不孕症的女性中更为强烈.
结论:
- 子宫内膜异位症和子宫内膜异位体多显著相关,每一种情况都会增加对方的风险.
- 这种同时发生的情况在患有不孕症的女性中尤为明显.
- 研究结果强调需要加强诊断方法和有针对性的干预措施,以改善受影响妇女的生育结果.
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