在具有精神分裂特征,下值抑郁症和自闭症特征的个体中,在适应编码期间改变后部中皮层激活
Ling-Ling Wang1, Yan Gao2, Chao Yan3
1School of Psychology, Shanghai Normal University, Shanghai, China.
Journal of psychiatric research
|November 29, 2025
概括
适应性编码受损,大脑中的适应性编码受损.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 认知科学 认知科学
背景情况:
- 无情是精神分裂症,严重抑郁症和自闭症谱系障碍的常见症状.
- 适应性编码,大脑将神经输出重新调整到上下文中,与无情感有关.
- 适应编码的神经相关物在精神分裂特征 (ST),下值抑郁症 (SD) 和自闭症特征 (AT) 中未得到充分研究.
研究的目的:
- 为了比较ST,SD和AT个体与健康对照 (HC) 个体的适应编码的神经相关物.
- 调查适应性编码表现和跨群体的无情症症状之间的关系.
主要方法:
- 使用适应性货币激励延迟任务的fMRI研究在35个ST,35个SD,23个AT和34个HC.
- 行为自适应编码任务和自我报告问卷对anhedonia.
- 在预期值 (EV) 和结果值 (OV) 适应过程中神经激活的分析.
主要成果:
- 与HC相比,ST,SD和AT组在EV适应过程中表现出后部中皮质 (pMCC) 的过度激活,而HC组则表现出后部中皮质的过度激活.
- 在OV适应过程中,SD组在补充运动区域 (SMA) 显示过度激活.
- 神经和行为自适应编码性能与ST,SD和AT组的快乐体验相关.
结论:
- 在ST,SD和AT中存在适应编码的共享和独特的异常神经模式.
- 非典型的自适应编码性能与这些亚临床组中的无情有关.
- 适应性编码是无虫干预和预防的潜在目标.
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