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定向乳酸生产可以减轻抗生素和ARG污染

Fubin Yin¹, Tianjing Lian², Haoying Qu¹

¹Institute of Environment and Sustainable Development in Agriculture, Chinese Academy of Agricultural Sciences, 12 Southern Street of Zhongguancun, Beijing 100081, China.

Journal of biotechnology

|November 29, 2025

概括

乳酸细菌有效降解硫酸化 (SCP) 并降低抗生素耐药性基因 (ARG). 这项研究表明,定向乳酸生产 (DLAP) 的潜力可以减轻动物便中的抗生素污染.

科学领域:

环境微生物学环境微生物学
生物技术是生物技术.
废物管理废物管理

背景情况:

动物便中的抗生素残留物对环境构成风险.
这些残留物对增值工艺,如定向乳酸生产 (DLAP) 的影响尚不清楚.
乳酸细菌 (LAB) 是发酵过程中的关键参与者.

研究的目的:

通过常见的LAB.来研究硫烯酸 (SCP) 的降解.
确定降解途径和对抗生素耐药性基因 (ARG) 的影响.
评估DLAP用于抗生素和ARG修复的可行性.

主要方法:

使用了四种LAB物种 (Lactobacillus bulgaricus,L. acidophilus,L. plantarum,L. casei) 的纯培养物.
分析了SCP降解速率和途径.
量化了特定ARG (sul1, sul2, sul3, sulA, intI1, tnpA) 的减少情况.

主要成果:

实验室实验室显著降低了ARG,包括sul1, sul2, sul3, sulA,intI1和tnpA.
根据LAB,SCP降解率在50 mg/L时从84.0%到90.3%不等.
在LAB物种中,SCP降解涉及类似的关键功能,产生毒性较低的中间体.

结论:

实验室有效降低SCP和减少ARG,表明它们在生物修复中的潜力.
DLAP过程显示出对管理动物便中抗生素和ARG污染的前景.
这项研究为优化DLAP的环境净化提供了基础.

关键词:

抗生素抗生素是一种抗生素.抗生素耐药性基因是抗生素耐药性的基因.降解途径的降解途径牛奶酸是什么牛奶酸是什么猪便是猪便的一种.

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