血清谷氨的升高反映了炎症性肠病中的内镜性疾病活性
Sem Geertsema1, Hannah J Holstein1, Marian L C Bulthuis2
1Department of Gastroenterology and Hepatology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
血清谷氨 (GSH) 显示出作为炎症性肠病 (IBD) 内学活动的生物标志物具有前景,特别是在克罗恩病 (CD) 中. 将GSH与便calprotectin相结合,可显著提高IBD监测的诊断准确性.
科学领域:
- 胃肠病学 胃肠病学
- 生物标志物 生物标志物
- 氧化压力是一种氧化压力.
背景情况:
- 系统性氧化应激和氧化还原失衡是炎症性肠病 (IBD) 病理生理学的关键.
- 之前的研究将氧化应激与IBD内镜性疾病活动联系起来.
研究的目的:
- 预期评估氧化还原蛋白 (自由硫醇,硫-1) 作为IBD患者内镜性疾病活性的生物标志物.
- 评估血清谷氨 (GSH) 和其他醇生物标志物与IBD活动的关联.
主要方法:
- 111名接受监视内镜检查的IBD患者提供了血液样本.
- 评估的血清/血生物标志物:自由硫醇 (FTs),GSH,缺血变异性白蛋白 (IMA),同类半氨酸,半氨酸, thioredoxin-1.
- 相关的生物标志物水平与内镜评分 (Mayo,SES-CD) 使用后勤回归.
主要成果:
- 血清GSH与活性内镜性疾病 (OR 4.19) 显著相关,特别是在克罗恩病 (CD) 中.
- 虽然GSH的准确性很好 (CD中的AUC为0.71,UC中的AUC为0.65),但其表现优于便中的calprotectin (AUC为0.77).
- 将GSH与便calprotectin结合使用显著改善了诊断区分 (AUC 0.95).
结论:
- 血清GSH是一种潜在的系统生物标志物,用于IBD,特别是CD中的内镜性疾病活性.
- 系统性氧化应激标志物,如GSH,补充便calprotectin,以加强IBD监测.
- 铁素-1和自由硫醇随着结肠疾病的活动增加.
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