患病鼻综合征在心房的患者中增加了中风风险,心房的患者的CHA2DS2-VASC得分较低
Sheng-Nan Chang1, Pang-Shuo Huang2, Jien-Jiun Chen3
1Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital Yun-Lin Branch, Yun-Lin, Taiwan.
Heart rhythm
|November 29, 2025
概括
病鼻综合征 (SSS) 独立地增加了心房动 (AF) 患者中风风险. 这种风险在具有较低CHA2DS2-VASc分数的患者中最为明显,这表明需要量身定制的预防策略.
科学领域:
- 心脏病学 心脏病学
- 神经学 神经学
- 临床医学 临床医学
背景情况:
- 心房动 (AF) 和恶性鼻综合征 (SSS) 是已知的中风风险因素.
- SSS对AF患者中风风险的综合影响尚不清楚.
研究的目的:
- 确定SSS是否是诊断为AF的患者中发生性缺血性中风的独立预测因素.
- 调查AF群体中SSS和中风风险之间的关联.
主要方法:
- 一项基于医院的队列研究包括从2010年到2021年的24960名AF患者.
- SSS被定义为症状性鼻节功能障碍,需要心脏起器植入.
- 用CHA2DS2-VASc分数调整后的Cox比例危险模型来评估中风风险.
主要成果:
- 患有SSS的患者 (n=1624) 与没有SSS的患者 (n=23,336,3.03%的患者年) 相比,缺血性中风的发病率更高 (每年4.02%).
- SSS独立地与23%的中风风险增加有关 (HR 1.23,95% CI 1.10-1.37).
- 这种关联在CHA2DS2-VASc得分≤2 (HR 2.13) 的患者中是显著的,但在得分>2 (HR 1.02) 的患者中并非显著.
结论:
- 病鼻综合征是心房动患者缺血性中风的独立危险因素.
- 与SSS相关的中风风险增加,特别明显在有较低CHA2DS2-VASc分数的AF患者中.
- 这些发现可能会为患有SSS的AF患者提供更精确的中风预防策略.
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