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Yuehui Tian¹, Shanshan Xu¹, Zidong Ye¹

¹Guangdong Provincial Key Laboratory of Plant Adaptation and Molecular Design, Innovation Center for Cell Signal Transduction and Synthetic Biology, School of Life Sciences, Guangzhou University, Guangzhou 510006, China.

Biotechnology advances

|November 29, 2025

概括

光遗传工具提供精确的,基于光的控制细胞过程,推进合成生物学. 这些工具可以实现酶和基因表达的时空调节,以改善生物生产和研究.

科学领域:

合成生物学合成生物学
生物技术是生物技术.
分子生物学分子生物学

背景情况:

化学生产中酶修饰和基因调节的传统方法是有限的.
光遗传工具提供了对酶活性和基因表达的时空控制,克服了化学诱导的局限性.

研究的目的:

审查近期光遗传工具在微生物代谢物,植物科学和疾病治疗中的应用.
根据它们在生物调节中的独特应用,对光遗传工具进行分类.

主要方法:

将光遗传工具根据功能分为五个类别.
讨论应用,包括光诱导的基因表达,相分离,亚细胞定位,酶调节和离子通道/利用.

主要成果:

光遗传工具使光诱导基因表达能够平衡细胞生长和生产.
光触发液态液相分离 (LLPS) 模块提高了酶的催化效率.
光遗传工具有助于循环核酸,蛋白质功能和离子信号的动态调节.

结论:

光遗传学策略为推进基础研究和生物工业提供了强大的工具.
这些工具为优化生物产品产量和理解复杂的生物系统提供了精确的控制.

关键词:

生物产品是生物产品.关键的信号节点关键的信号节点多光谱应用.视觉遗传学视觉遗传学时间空间调节.合成生物学合成生物学

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