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快速全脑静脉脑血体积测绘使用3D GRASE的速度选择性静脉旋转标记

Youngho Heo¹, Sung Suk Oh², Won Beom Jung³

¹Emotion, Cognition & Behavior Research Group, Korea Brain Research Institute, Daegu, South Korea; School of Electronic and Electrical Engineering & IEDT, Kyungpook National University, Daegu, South Korea.

|November 29, 2025

概括

一种新的快速3DMRI技术在不到一分钟的时间内准确地绘制了整个大脑的静脉脑血量 (CBV). 这种速度选择性VSL-3D GRASE方法显示出高可重现性和对生理挑战的敏感性.

科学领域:

神经成像是一种神经成像.
生理学生理学生理学
磁共振成像是一种磁共振成像技术.

背景情况:

静脉大脑血液体积 (CBV_v) 是一个关键的神经生理学参数,影响了BOLD信号.
目前用于CBV_v映射的非侵入性MRI方法受到磁场工件和长时间扫描的限制.

研究的目的:

开发一种快速的全脑3DCBV_v映射技术,解决现有方法的局限性.
将速度选择性静脉旋转标记 (VS-VSL) 与3D梯度和旋转回声 (GRASE) 序列相结合,以提高效率和精度.

主要方法:

开发了一种使用VS-VSL和3D GRASE读数的快速全脑3D CBV_v映射技术.
使用模拟来优化扫描效率和估计准确性的GRASE参数.
在健康人群中验证了优化方案,评估了可重现性和对生理挑战 (屏息,咖啡因) 的敏感性.

主要成果:

该VS-VSL 3D GRASE序列在60秒内实现了整个大脑的3D CBV_v映射.
在灰质 (R²/ICC = 0.88/0.93) 和白质 (R²/ICC = 0.76/0.87) 中证明了高的测试重复测试可重复性.
成功检测出对呼吸暂停 (+26.8% GM, +31.2% WM) 和咖啡因摄入量 (-16.3% GM, -14.1% WM) 的显著CBV_v变化.

结论:

开发的VS-VSL 3D GRASE技术为全脑3D CBV_v映射提供了一个快速可靠的方法.
这种技术对未来的神经成像研究具有前途,需要空间和时间解析的CBV测量.
该方法对生理学挑战的敏感性凸显了其临床和研究应用的潜力.

关键词:

脑子脑子脑子脑子大脑血液体积 (CBV)这是草地.这就是为什么MRI是MRI.速度选择性的旋转标签静脉CBV病毒的发生.

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