是朋友还是敌人? 通过利基重塑的镜头将Bacteroides语境化
Ryan T Fansler1, Yifan Wu1, Wenhan Zhu1
1Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Vanderbilt Institute for Infection, Immunology, and Inflammation, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Trends in microbiology
|November 29, 2025
概括
细菌的细菌可以是有益的共生者和有害的病原体. 它们的双重作用取决于它们如何重塑肠道环境,影响肠道平衡和疾病.
科学领域:
- 微生物学 微生物学
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
背景情况:
- 细菌类是肠道微生物群的关键成员,对于维持肠道平衡至关重要.
- 新出现的证据表明,Bacteroides还可以促进疾病,增加对感染的易感性和驱动肠道炎症.
研究的目的:
- 为了调和细菌类的双重角色,即作为共生生物和病原体.
- 探索这种概念,即Bacteroides的致病潜力与其重塑肠道的能力有关.
主要方法:
- 本综述综合了最近的研究发现.
- 专注于细菌菌类的利基重塑的分子和生态机制.
主要成果:
- 细菌菌的致病潜力与肠道改造的程度相关.
- 细菌体对的改造影响了宿主对疾病和炎症状况的易感性.
结论:
- 了解 Bacteroides 的上下文依赖行为对于区分有益和有害的角色至关重要.
- 最近的进展揭示了 Bacteroides 对肠道健康和疾病的利基改造的影响.
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