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对羊角发育中的FGF2基因的功能分析和关键调控变异的识别

Fei Liu^1,2,3, Hao Li^2,3, Zhu Meng^2,3

¹College of Animal Science and Technology, Qingdao Agricultural University, Qingdao, 266109, China.

|November 29, 2025

概括

研究人员确定了纤维细胞生长因子2 (FGF2) 基因.

科学领域:

遗传学是一个遗传学.
发展生物学发展生物学
动物科学动物科学

背景情况:

角是羊的重要特征,但存在管理风险.
了解角的发育有助于培育受访的羊品种.

研究的目的:

研究纤维细胞生长因子2 (FGF2) 在羊角发育中的作用.
确定影响角形态的遗传和调节因素.

主要方法:

利用了多组学方法,包括RNA测序 (RNA-seq) 和全基因组测序 (WGS).
分析了特定组织的基因表达,确定了功能变异,并集成了表观基因组数据.
进行了种群遗传分析,KASP基因型定型和等位基因特异性表达 (ASE) 分析.

主要成果:

FGF2表达特异于角和皮肤组织,在大角羊中更高.
确定了与角长度相关的显著单核酸多态 (SNP),位于增强器区域.
发现了特定物种的氨基酸变体和三个ASE位点.

结论:

FGF2基因影响绵羊角的发育,可能通过调节增强剂活性.
已识别的SNP和ASE地点作为有价值的分子标记物用于养受访绵羊.

关键词:

在FGF2上.对等位基特异性的表达.监管要素是一个监管要素.绵羊的角是羊的角.组织特异性的组织特异性的组织.

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Determination

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