怀孕相关的乳腺癌:孕期体重增加的影响和名谱验证
Chenguang Liu1,2, Ruifeng Wang3, Shoujun Wang1
1Department of Thyroid and Breast Surgery, Tianjin Key Laboratory of General Surgery, Tianjin Union Medical Center, The First Affiliated Hospital of Nankai University, 190 Jieyuan Road, Hongqiao District, Tianjin, 300121, China.
BMC cancer
|November 29, 2025
概括
与怀孕相关的乳腺癌 (PABC) 患者的预后比非PABC患者的预后更差. 妊娠期体重增加 (GWG) 是一个关键的风险因素,一个新的名谱有助于预测PABC患者的无疾病生存期 (DFS).
科学领域:
- 在瘤学瘤学.
- 生殖医学 生殖医学
- 生物统计学 生物统计学
背景情况:
- 与怀孕相关的乳腺癌 (PABC) 是罕见的,预后因素不明.
- 现有的关于PABC预后和影响因素的知识不足以进行有效的临床管理.
研究的目的:
- 确定影响PABC患者无病生存 (DFS) 的预后因素.
- 开发和验证用于PABC预后的预测性名谱.
主要方法:
- 从三所高等机构对PABC和非PABC患者的回顾性分析.
- 考克斯的比例危险回归模型用于确定DFS的独立预后因素.
- 开发和验证使用一致性指数,校准曲线,ROC和决策曲线分析的预后名ogram.
主要成果:
- 与非PABC患者相比,PABC患者表现出较差的临床病理特征和预后.
- 妊娠期体重增加 (GWG) 被确定为PABC中影响DFS的独立预后因素.
- 一个经过验证的名图显示,在PABC患者中,DFS的预测准确度强大.
结论:
- PABC与非PABC的预后更差,GWG是与怀孕相关的重要风险因素.
- 开发的诺米图是预测PABC预后和为临床决策提供信息的宝贵工具.
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