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Updated: Jan 9, 2026

Strand-Specific Analysis of Proteins at Replicating DNA Strands by Enrichment and Sequencing of Protein-Associated Nascent DNA Method
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Published on: May 2, 2025

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核细胞膜A/C通过调节局部H3K9me3和ADP-ribosylation水平来控制复制叉在压力时重新启动

Veronica Cherdyntseva1, Joanna Paulson2, Daniel González-Acosta1

  • 1Institute of Molecular Cancer Research, University of Zurich, Zurich, Switzerland.

Nature communications
|November 29, 2025
PubMed
概括

核胺A/C蛋白对于在轻度复制应激 (RS) 期间减缓DNA复制叉来说至关重要,这是癌症化学疗法的关键策略. 它的损失会破坏叉子的稳定性和重新启动,影响治疗反应.

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