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在被囚禁的动物Octodon degus中,对宿主生理学,行为和肠道微生物组的营养调节

Daniela S Rivera¹, Valentina Beltrán², Claudia Hoepfner^2,3

¹GEMA Center for Genomics, Ecology & Environment, Universidad Mayor, Santiago, Chile. daniela.rivera@umayor.cl.

Scientific reports

|November 29, 2025

概括

饮食通过改变肠道微生物,显著影响了认知和行为. 实验室饮食增强了营养吸收和记忆,但增加了焦虑,而冠军饮食促进了微生物多样性和减少了焦虑,突出了饮食.

科学领域:

神经科学是一个神经科学.
微生物组研究微生物组研究
动物模型动物模型

背景情况:

饮食对健康至关重要,影响新陈代谢,体重和精神健康.
肠-大脑轴通过微生物代谢产物调解饮食对认知的影响.
八虫是衰老和认知研究的一个新兴模型,但饮食-微生物组-认知联系尚未被探索.

研究的目的:

为了比较LabDiet和Champion饮食对消化效率,行为和肠道微生物群的影响.
分析饮食-微生物组-认知关系,使用零碎结构方程建模 (pSEM).

主要方法:

两种动物饮食 (LabDiet和Champion) 在Octodon degus.中的比较.
评估消化效率,行为测试 (工作记忆,社会动机,焦虑) 和肠道微生物组组成.
使用零碎结构方程建模 (pSEM) 的统计分析.

主要成果:

实验室饮食增加了营养吸收,便酸和阿基诺细菌 (Bifidobacterium),改善工作记忆和社会动机,但增加了焦虑.
冠军饮食,富含多种植物纤维,增加了肠道微生物的丰富性和Bacteroidota/Tenericutes的丰富性,减少了焦虑.
饮食成分显著影响了微生物活动,酸与认知表现有积极的相关性.

结论:

饮食是影响degu生理学,认知和微生物生态学的关键因素.
标准化degu饮食对于行为和生物医学研究中的研究可重复性至关重要.
肠道微生物组通过短链脂肪酸 (SCFA) 调解饮食驱动的大脑功能,使得格斯对研究衰老和心理健康有价值.

关键词:

细菌细菌是一种细菌.认知认知是一种认知.饮食饮食饮食饮食脂肪酸是一种脂肪酸.肠-大脑轴 - 肠-大脑轴

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